"Goodnight, Irene" or "Irene, Goodnight," is a 20th century American folk standard. The lyrics tell how the singer lost his love through "rambling and gambling". He contemplates suicide in the famous line "Sometimes I take a great notion to jump in the river and drown". The final verse urges the listener to "go home to your wife and family". In addition to many recorded versions, it is also a favorite camp and fireside song.

Some sources, including blues scholar Paul Oliver, claim the version popularized by Lead Belly in the 1940s, which he titled just "Irene," is based on the 1886 pop song by Gussie L. Davis. Lead Belly himself said he had learned it from his uncle. It was a US #1 hit for folk group The Weavers in 1950. The song is written in 3/4 time.

It has since been recorded by a number of artists, in pop, country, folk and rock styles (see list below). In 2002, Lead Belly's 1936 Library of Congress recording received a Grammy Hall of Fame Award. English football (soccer) club Bristol Rovers have adopted it as their "club song" and the fans often sing it during matches.